Deltasone (Prednisolone)

Common Use

Prednisolone is a synthetic analogue of the hormones cortisone and hydrocortisone. The drug causes significant anti-inflammatory, antiallergic, anti-exudative, antishock, and anti-toxic effects. The anti-inflammatory effect of prednisolone is primarily associated with cytosolic glucocorticosteroid receptors. The complex between the hormone and the receptor penetrates the nucleus of the target skin cell, enhancing the expression of genes that code for lipoprotein synthesis. These lipoproteins inhibit phospholipase A2, reducing the synthesis of arachidonic acid metabolites known to participate in inflammatory reactions. The antiallergic effect of prednisolone is due to its ability to decrease the number of basophils and inhibit the synthesis and secretion of biologically active substances. Prednisolone is used to treat various conditions, including allergic disorders, collagenosis (skin conditions), infectious nonspecific polyarthritis, psoriasis, lupus, ulcerative colitis, bronchial asthma, acute lymphoblastic and myeloid leukemia, neurodermatitis, eczema, Addison’s disease, and more.

Dosage and Direction

Individual dosing is necessary for each condition. Acute conditions typically require an initial dose of 5-60 mg per day, with a maintenance dose of 5-10 mg per day. Do not take more of Prednisolone than prescribed. Follow all recommendations from your doctor.

Precautions

Inform your doctor about all diseases you have, especially liver or kidney disease, thyroid disorder, diabetes, tuberculosis, malaria, myasthenia gravis, stomach ulcers, glaucoma, or mental illness, as steroid use may affect these conditions. Steroid medications are known to weaken the immune system, making infections more likely. Avoid contact with sick people, and inform your doctor if you have been exposed to chickenpox or measles, as these can be extremely dangerous for people taking steroids. Do not receive live vaccines during Prednisolone treatment. Avoid sudden discontinuation of Prednisolone to prevent withdrawal symptoms. Inform your doctor if you are pregnant.

Contraindications

This medication is contraindicated in patients with severe hypertension, diabetes, Itsenko-Cushing syndrome, pregnancy, severe circulatory failure, acute endocarditis (inflammation of the inner heart cavities), psychosis, nephritis, osteoporosis, stomach and duodenal ulcers, recent surgery, syphilis, active tuberculosis, or in elderly patients.

Side Effects

This medication may cause side effects such as obesity, hirsutism (excessive body hair growth in women), acne, menstrual disorders, osteoporosis, Itsenko-Cushing syndrome (obesity, decreased sexual function, bone fragility), gastrointestinal ulceration, ulcer perforation, hemorrhagic pancreatitis, hyperglycemia (high blood sugar), increased blood clotting, and mental disorders. Withdrawal symptoms are possible, especially after prolonged treatment. Contact your doctor if you experience worsening side effects, including changes in vision, depression, seizures, bloody or tarry stools, low potassium (increased urination, extreme thirst, uneven heart rate), or hypertension.

Drug Interaction

Concomitant use of Prednisolone with anti-diabetic and anticoagulant drugs may require dose adjustments. In patients with Addison’s disease, concurrent use of Prednisolone and barbiturates should be exercised with caution.

Missed Dose

If you forget to take your dose on time, contact your doctor or healthcare advisor.

Overdose

This medication is unlikely to cause life-threatening symptoms. However, prolonged use can lead to adverse effects such as easy bruising, thinning skin, accumulation of body fat in the back, face, neck, and waist, acne, facial hair growth, impotence, and menstrual issues.

Storage

Store at room temperature between 20-25°C (68-77°F). Keep away from moisture, heat, and sunlight. Do not store in a bathroom, and keep out of reach of children.